Oxidized phospholipids formed in oxidized LDL
نویسندگان
چکیده
منابع مشابه
Oxidized phospholipids, linked to apolipoprotein B of oxidized LDL, are ligands for macrophage scavenger receptors.
Previous studies have shown that macrophage receptors for oxidized LDL (OxLDL) recognize both the lipid and protein moieties, and that a monoclonal antibody against OxLDL, EO6, also recognizes both species. The present studies show directly that during LDL oxidation phospholipids become covalently attached to apolipoprotein B (apoB). After exhaustive extraction of lipids, apoB of native LDL con...
متن کاملInflammatory profile of oxidized phospholipids.
Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the proatherogenic and proinflammatory effects, OxPL can stimulate antiinflammato...
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A great variety of biochemical processes are either confined to or mediated by cellular membranes constructed around a framework provided by a compositionally heterogeneous and highly dynamic bilayer of phospholipid molecules. Accordingly, the physical properties and molecular organization of these mesoscopic supramolecular assemblies are regarded to represent pivotal determinants of the overal...
متن کاملDifferential Trafficking of Oxidized LDL and Oxidized LDL Immune Complexes in Macrophages: Impact on Oxidative Stress
BACKGROUND Oxidized low-density lipoproteins (oxLDL) and oxLDL-containing immune complexes (oxLDL-IC) contribute to formation of lipid-laden macrophages (foam cells). It has been shown that oxLDL-IC are considerably more efficient than oxLDL in induction of foam cell formation, inflammatory cytokines secretion, and cell survival promotion. Whereas oxLDL is taken up by several scavenger receptor...
متن کاملMinimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages.
OBJECTIVE Lipid-loaded macrophage-derived foam cells populate atherosclerotic lesions and produce many pro-inflammatory and plaque-destabilizing factors. An excessive accumulation of extensively oxidized low-density lipoprotein (OxLDL) or free cholesterol (FC), both of which are believed to be major lipid components of macrophages in advanced lesions, rapidly induces apoptosis in macrophages. I...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 2001
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.28.3_63